Olmesartan ameliorates urinary dysfunction in the spontaneously hypertensive rat via recovering bladder blood flow and decreasing oxidative stress. Issue 3 (17th June 2013)

• Record Type: Journal Article
• Authors: Shimizu, Shogo; Saito, Motoaki; Oiwa, Harunori; Ohmasa, Fumiya; Tsounapi, Panagiota; Oikawa, Ryo; Dimitriadis, Fotios; Martin, Darryl T.; Satoh, Itaru; Kinoshita, Yukako; Tomita, Shuhei
• Is Part Of: Neurourology and urodynamics. Volume 33:Issue 3(2014:Mar.)
• Page Start: 350
• Page End: 357
• Publication Date: 2013-06-17
• Subjects: Urinary organs -- Periodicals; Urodynamics -- Periodicals; Urology -- Periodicals; 616.6
• DOI: 10.1002/nau.22405
• Languages: English
• ISSNs: 0733-2467

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="nau22405-sec-0001" sec-type="section"> <title>Purpose</title> <p>As hypertension (HT) is one of the risk factors for lower urinary tract symptoms, we investigated the effect of an angiotensin II type I receptor blocker, olmesartan, on bladder dysfunction in the spontaneously hypertensive rat (SHR).</p> </sec> <sec id="nau22405-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Twelve‐week‐old male SHRs were administered perorally with olmesartan (0, 1, or 3 mg/kg/day) or nifedipine (30 mg/kg/day) for 6 weeks. Wistar rats were used as normotensive controls. The effects of olmesartan or nifedipine on blood pressure (BP), bladder blood flow (BBF), urodynamic parameters, tissue levels of malondialdehyde (MDA), nuclear factor erythroid 2‐related factor 2 (Nrf2), and nerve growth factor (NGF) were measured in the bladder. Localization of 4‐hydroxy‐2‐nonenal (4‐HNE), Nrf2, and NGF in the bladder was shown by immunohistochemistry.</p> </sec> <sec id="nau22405-sec-0003" sec-type="section"> <title>Results</title> <p>The SHRs showed significant increase in BP, micturition frequency, and expression of MDA, 4‐HNE, Nrf2, and NGF when compared to the control Wistar rats. Conversely, there was a decrease in BBF and single voided volume in SHRs when compared to Wistar rats. Treatment with olmesartan and nifedipine significantly improved BP. However, only olmesartan significantly ameliorated urodynamic parameters and oxidative damage compared to the non‐treated SHR. The immunoreactivities of 4‐HNE, Nrf2, and NGF in SHR urothelium and blood vessels were increased compared to the control. Treatment with a high dose of olmesartan decreased the expressions of 4‐HNE, Nrf2, and NGF in the bladder.</p> </sec> <sec id="nau22405-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Our data suggest that BP, BBF, and oxidative stress may be responsible for the functional changes in HT‐related bladder dysfunction. Olmesartan significantly ameliorated this bladder dysfunction. <italic>Neurourol. Urodynam. 33:350–357, 2014</italic>. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>