Effect of glucose concentration on peripheral nerve and its response to anoxia. Issue 3 (16th December 2013)

• Record Type: Journal Article
• Authors: Stecker, Mark M.; Stevenson, Matthew
• Is Part Of: Muscle & nerve. Volume 49:Issue 3(2014:Mar.)
• Page Start: 370
• Page End: 377
• Publication Date: 2013-12-16
• Subjects: Neuromuscular diseases -- Periodicals; Muscles -- Periodicals; Nerves -- Periodicals; 616.74
• DOI: 10.1002/mus.23917
• Languages: English
• ISSNs: 0148-639X

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p> <italic>Introduction</italic>: Glucose has a significant effect on nerve function. <italic>Methods</italic>: The effects of glucose on the nerve action potential (NAP) were investigated for concentrations between 0 and 55.5 mmol/L in an <italic>in vitro</italic> system using rat sciatic nerve. The effects of glucose were investigated in nerves exposed to oxygenated perfusate and those subjected to anoxia. Multiple aspects of the NAP were analyzed. <italic>Results</italic>: Hypoglycemia produces immediate reductions in NAP amplitude and velocity, whereas hyperglycemia has the opposite effect in the short term. Over a 12‐hour experiment, the amplitude of the NAP remained stable for glucose concentrations in the range 2.8–5.6 mmol/L, but, when the glucose concentration was &lt;2.8 mmol/L or &gt;27.8 mmol/L, the amplitude of the NAP declined. The deleterious effects of hyperglycemia (≥27.8 mmol/L) or hypoglycemia (&lt;4.2 mmol/L) were more pronounced in nerves exposed to intermittent anoxia. <italic>Conclusions</italic>: This findings confirm the importance of glucose concentration for nerve function especially during anoxia. <italic>Muscle Nerve</italic><bold>49</bold>:370–377, 2014</p> </abstract>