Association study in three different populations between the GPR88 gene and major psychoses. Issue 2 (12th December 2013)

• Record Type: Journal Article
• Authors: Del Zompo, Maria; Deleuze, Jean‐François; Chillotti, Caterina; Cousin, Emmanuelle; Niehaus, Dana; Ebstein, Richard P.; Ardau, Raffaella; Macé, Sandrine; Warnich, Louise; Mujahed, Mustafa; Severino, Giovanni; Dib, Colette; Jordaan, Esme; Murad, Ibrahim; Soubigou, Stéphane; Koen, Liezl; Bannoura, Issam; Rocher, Corinne; Laurent, Claudine; Derock, Murielle; Faucon Biguet, Nicole; Mallet, Jacques; Meloni, Rolando
• Is Part Of: Molecular genetics & genomic medicine. Volume 2:Issue 2(2014:Mar.)
• Page Start: 152
• Page End: 159
• Publication Date: 2013-12-12
• Subjects: Medical genetics -- Periodicals; Genomics -- Periodicals; 616.042
• DOI: 10.1002/mgg3.54
• Languages: English
• ISSNs: 2324-9269

Abstract

<abstract abstract-type="main" id="mgg354-abs-0001"> <title>Abstract</title> <p> <italic>GPR88</italic>, coding for a G protein‐coupled orphan receptor that is highly represented in the striatum, is a strong functional candidate gene for neuropsychiatric disorders and is located at 1p22‐p21, a chromosomal region that we have previously linked to bipolar disorder (BD) in the Sardinian population. In order to ascertain the relevance of <italic>GPR88</italic> as a risk factor for psychiatric diseases, we performed a genetic association analysis between <italic>GPR88</italic> and BD in a sample of triads (patient and both parents) recruited in the Sardinian and the Palestinian population as well as between <italic>GPR88</italic> and schizophrenia (SZ) in triads from the Xhosa population in South Africa. We found a positive association between <italic>GPR88</italic> and BD in the Sardinian and Palestinian triads. Moreover, we found a positive association between <italic>GPR88</italic> and SZ in triads from the Xhosa population in South Africa. When these results were corrected for multiple testing, the association between <italic>GPR88</italic> and BD was maintained in the Palestinian population. Thus, these results suggest that <italic>GPR88</italic> deserves consideration as a candidate gene for psychiatric diseases and requires to be further investigated in other populations.</p> </abstract>