Extranodal natural killer/T‐Cell lymphoma: A population‐based comparison of sinonasal and extranasal disease. (7th October 2013)

• Record Type: Journal Article
• Authors: Vazquez, Alejandro; Khan, Mohemmed N.; Blake, Danielle M.; Sanghvi, Saurin; Baredes, Soly; Eloy, Jean Anderson
• Is Part Of: Laryngoscope. Volume 124:Number 4(2014:Apr.)
• Page Start: 888
• Page End: 895
• Publication Date: 2013-10-07
• Subjects: Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.24371
• Languages: English
• ISSNs: 0023-852X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="lary24371-sec-0001" sec-type="section"> <title>Objectives/Hypothesis</title> <p>Extranodal natural killer/T‐cell Lymphoma (ENKTL) is a rare, aggressive malignancy that preferentially affects the paranasal region. This study analyzes the demographic, clinicopathologic, incidence, and survival characteristics of sinonasal ENKTL (SN‐ENKTL) and extranasal ENKTL (EN‐ENKTL) in a comparative fashion.</p> </sec> <sec id="lary24371-sec-0002" sec-type="section"> <title>Study Design</title> <p>Retrospective analysis.</p> </sec> <sec id="lary24371-sec-0003" sec-type="section"> <title>Methods</title> <p>The Surveillance, Epidemiology, and End Results database was queried; 528 cases were available for frequency and incidence analysis, and 473 for survival analysis. Data were examined according to age, gender, race, histology, the presence of systemic (or B) symptoms, treatment, and Ann Arbor stage.</p> </sec> <sec id="lary24371-sec-0004" sec-type="section"> <title>Results</title> <p>Extranasal disease was a poor prognostic factor (hazard ratio [HR] = 1.69, 95% confidence interval [CI] = 1.30−2.19, <italic>P</italic> < .05). Patients with EN‐ENKTL were older (mean 53.8 vs. 49.9 years, <italic>P</italic> < .05), most were male (72.5% vs. 59.8%, <italic>P</italic> < .05), and they were more likely to present with stage IIIE/IV disease (38.33% vs. 18.26%, <italic>P</italic> < .05). B symptoms were present in 38.41% of the EN‐ENKTL group (vs. 22.86%, <italic>P</italic> < .05), and were a poor prognostic factor in this group only (HR = 1.6593, 95% CI = 1.05−2.62, <italic>P</italic> < .05). Radiation therapy demonstrated a survival advantage among both groups, especially in early stage disease.</p> </sec> <sec id="lary24371-sec-0005" sec-type="section"> <title>Conclusions</title> <p>SN‐ENKTL carries a significantly better prognosis than EN‐ENKTL, which presents at more advanced stages. Radiation therapy was associated with increased survival in both groups, especially in cases of localized disease.</p> </sec> <sec id="lary24371-sec-0006" sec-type="section"> <title>Level of Evidence</title> <p>2b. <italic>Laryngoscope</italic>, 124:888–895, 2014</p> </sec> </abstract>