Electrochemotherapy for the management of cutaneous and subcutaneous metastasis: A series of 39 patients treated with palliative intent. Issue 3 (28th October 2013)

• Record Type: Journal Article
• Authors: Solari, Nicola; Spagnolo, Francesco; Ponte, Erica; Quaglia, Alberto; Lillini, Roberto; Battista, Michela; Queirolo, Paola; Cafiero, Ferdinando
• Is Part Of: Journal of surgical oncology. Volume 109:Issue 3(2014:Mar. 01)
• Page Start: 270
• Page End: 274
• Publication Date: 2013-10-28
• Subjects: Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.23481
• Languages: English
• ISSNs: 0022-4790

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jso23481-sec-0001" sec-type="section"> <title>Background and Objectives</title> <p>Electrochemotherapy (ECT) is technique for local control of skin metastasis. This study is primarily aimed at assessing the clinical activity of ECT in a prospective cohort of patients, and evaluating the association between primary tumor histology, number of metastatic lesions and size of tumor deposits and objective response rate.</p> </sec> <sec id="jso23481-sec-0002" sec-type="section"> <title>Methods and Results</title> <p>Thirty‐nine patients with skin metastases from melanoma and other tumors underwent intravenous bleomycin ECT with palliative intent. No serious adverse events (SAE) or CTC grade 3 or 4 were observed. Overall response rate (ORR) was 66.6%. Response rate significantly correlated at univariate analysis both with the number (< or >10) and the size (< or >2 cm) of metastases. No relationship was observed for the histology of primary tumor. At multivariate analysis the size of the nodules under 2 cm was associated with a positive response and the correlation was statistically significant.</p> </sec> <sec id="jso23481-sec-0003" sec-type="section"> <title>Conclusions</title> <p>ORR was 66.6% and all patients obtained a subjective clinical benefit from the treatment with minimal side effects. The most suitable patients were the ones with nodules <2 cm. <italic>J. Surg. Oncol. 2014 109:270–274</italic>. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>