Diffusion‐weighted imaging of the high‐risk breast: Apparent diffusion coefficient values and their relationship to breast density. Issue 4 (13th September 2013)

• Record Type: Journal Article
• Authors: O'Flynn, Elizabeth A.M.; Wilson, Robin M.; Allen, Steven D.; Locke, Imogen; Scurr, Erica; deSouza, Nandita M.
• Is Part Of: Journal of magnetic resonance imaging. Volume 39:Issue 4(2014)
• Page Start: 805
• Page End: 811
• Publication Date: 2013-09-13
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24243
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24243-sec-0001" sec-type="section"> <title>Purpose</title> <p>To document the apparent diffusion coefficient (ADC) of fibroglandular breast tissue in women at high‐risk of developing breast cancer and investigate the relationship between ADC and breast density.</p> </sec> <sec id="jmri24243-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Local research ethics approval was obtained. A total of 33 high‐risk women including 17 <italic>BRCA1/2</italic> mutation carriers (mean age, 43 years) and 16 women postmantle irradiation (mean age 40 years) underwent diffusion‐weighted MRI between days 6 and 16 of their menstrual cycle. ADC histograms from a region of interest in fibroglandular tissue and mammographic breast density measurements were obtained. Mean, percentile ADC values (10th, 25th, 50th, 75th, 90th) and skew were compared for the two groups; ADC and mammographic breast density were correlated.</p> </sec> <sec id="jmri24243-sec-0003" sec-type="section"> <title>Results</title> <p>Mean ADC values (×10<sup>−6</sup> mm<sup>2</sup>/s) were 2017 ± 197 in postmantle irradiated women and 1827 ± 289 in <italic>BRCA1/2</italic> mutation carriers (<italic>P</italic> = 0.035) with significant differences at all percentiles (<italic>P</italic> < 0.0001) but not skew (<italic>P</italic> = 0.44). ADC values showed weak positive correlation with mammographic breast density in <italic>BRCA1/2</italic> mutation carriers (<italic>r</italic> = 0.51, <italic>P</italic> = 0.043) but not in postmantle radiotherapy patients (<italic>r</italic> = 0.49, <italic>P</italic> = 0.13).</p> </sec> <sec id="jmri24243-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Higher ADC values seen in fibroglandular tissue postmantle irradiation compared with <italic>BRCA1/2</italic> mutation carriers has potential to improve tumor detection in these patients. Lack of correlation between ADC and breast density postmantle irradiation may be a result of microstructural changes. <bold>J. Magn. Reson. Imaging 2014;39:805–811.</bold> © <bold>2013 Wiley Periodicals, Inc</bold>.</p> </sec> </abstract>