Characterizing non‐gaussian, high b‐value diffusion in liver fibrosis: Stretched exponential and diffusional kurtosis modeling. Issue 4 (20th November 2013)

• Record Type: Journal Article
• Authors: Anderson, Stephan W.; Barry, Brian; Soto, Jorge; Ozonoff, Al; O'Brien, Michael; Jara, Hernan
• Is Part Of: Journal of magnetic resonance imaging. Volume 39:Issue 4(2014)
• Page Start: 827
• Page End: 834
• Publication Date: 2013-11-20
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24234
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24234-sec-0001" sec-type="section"> <title>Purpose</title> <p>To employ the stretched exponential and diffusional kurtosis models to study the non‐Gaussian behavior of diffusion‐related signal decay of the liver in an animal model of hepatic fibrosis.</p> </sec> <sec id="jmri24234-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>High b‐value diffusion imaging data (up to 3500 s/mm<sup>2</sup>) of ex vivo murine liver specimens was acquired using a 9.4 T MRI scanner. A simple monoexponential model as well as the stretched exponential and diffusional kurtosis models were employed to analyze the diffusion data, the results of which were correlated with liver histopathology.</p> </sec> <sec id="jmri24234-sec-0003" sec-type="section"> <title>Results</title> <p>Strong correlations between histopathological assessments of hepatic fibrosis and parameters derived from the stretched exponential and diffusional kurtosis models were found. Using Akaike's Information Criterion (AIC) analyses, the kurtosis model was found to result in an improved fit of the high b‐value diffusion data when compared to both the monoexponential and stretched exponential models.</p> </sec> <sec id="jmri24234-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The use of diffusional kurtosis or stretched exponential models, applied to the characterization of the non‐Gaussian behavior of the molecular diffusion of liver exhibited over an extended b‐factor range, affords the potential for an increased capability of magnetic resonance imaging (MRI) in the characterization of chronic liver disease. <bold>J. Magn. Reson. Imaging 2014;39:827–834.</bold> © <bold>2013 Wiley Periodicals, Inc</bold>.</p> </sec> </abstract>