Hybrid multidimensional T2 and diffusion‐weighted MRI for prostate cancer detection. Issue 4 (1st August 2013)

• Record Type: Journal Article
• Authors: Wang, Shiyang; Peng, Yahui; Medved, Milica; Yousuf, Ambereen N.; Ivancevic, Marko K.; Karademir, Ibrahim; Jiang, Yulei; Antic, Tatjana; Sammet, Steffen; Oto, Aytekin; Karczmar, Gregory S.
• Is Part Of: Journal of magnetic resonance imaging. Volume 39:Issue 4(2014)
• Page Start: 781
• Page End: 788
• Publication Date: 2013-08-01
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24212
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24212-sec-0001" sec-type="section"> <title>Purpose</title> <p>To study the dependence of apparent diffusion coefficient (ADC) and T<sub>2</sub> on echo time (TE) and b‐value, respectively, in normal prostate and prostate cancer, using two‐dimensional MRI sampling, referred to as "hybrid multidimensional imaging."</p> </sec> <sec id="jmri24212-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>The study included 10 patients with biopsy‐proven prostate cancer who underwent 3 Tesla prostate MRI. Diffusion‐weighted MRI (DWI) data were acquired at b = 0, 750, and 1500 s/mm<sup>2</sup>. For each b‐value, data were acquired at TEs of 47, 75, and 100 ms. ADC and T<sub>2</sub> were measured as a function of b‐value and TE, respectively, in 15 cancer and 10 normal regions of interest (ROIs). The Friedman test was used to test the significance of changes in ADC as a function of TE and of T<sub>2</sub> as a function of b‐value.</p> </sec> <sec id="jmri24212-sec-0003" sec-type="section"> <title>Results</title> <p>In normal prostate ROIs, the ADC at TE of 47 ms is significantly smaller than ADC at TE of 100 ms (<italic>P</italic> = 0.0003) and T<sub>2</sub> at b‐value of 0 s/mm<sup>2</sup> is significantly longer than T<sub>2</sub> at b‐value of 1500 s/mm<sup>2</sup> (<italic>P</italic> = 0.001). In cancer ROIs, average ADC and T<sub>2</sub> values do not change as a function of TE and b‐value, respectively. However, in many cancer pixels, there are large decreases in the ADC as a function of TE and large increases in T<sub>2</sub> as a function of b‐value. Cancers are more conspicuous in ADC maps at longer TEs.</p> </sec> <sec id="jmri24212-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Parameters derived from hybrid imaging that depend on coupled/associated values of ADC and T<sub>2</sub> may improve the accuracy of MRI in diagnosing prostate cancer. <bold>J. Magn. Reson. Imaging 2014;39:781–788.</bold> © <bold>2013 Wiley Periodicals, Inc.</bold></p> </sec> </abstract>