A short expedient synthesis of [14C]Ticlopidine. (27th January 2014)

• Record Type: Journal Article
• Authors: Hickey, Michael J.; Kingston, Lee P.; Allen, Paul H.; Johnson, Tim; Wilkinson, David J.
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 57:Number 3(2014)
• Page Start: 172
• Page End: 174
• Publication Date: 2014-01-27
• Subjects: Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3184
• Languages: English
• ISSNs: 0362-4803

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>To support the development of a reactive metabolite strategy, the preparation of several radiolabelled compounds such as [¹⁴C] Ticlopidine was required. In this report, we describe a facile and rapid synthesis of [¹⁴C] Ticlopidine starting from [¹⁴C] carbon dioxide. The compound was radiolabelled in the 2‐chloromethyl portion of the molecule with a specific activity of 53.4 mCi/mmol and with a radiochemical purity of 98.5%. Storage stability was best as the hydrochloride salt in an ethanol solution. Copyright © 2014 John Wiley &amp; Sons, Ltd.</p> </abstract>