Comparison of three hydroxyapatite/β‐tricalcium phosphate/collagen ceramic scaffolds: An in vivo study. Issue 4 (4th June 2013)

• Record Type: Journal Article
• Authors: Maté‐Sánchez de Val, José Eduardo; Mazón, Patricia; Guirado, José Luis Calvo; Ruiz, Rafael Arcesio Delgado; Ramírez Fernández, María Piedad; Negri, Bruno; Abboud, Marcus; De Aza, Piedad N.
• Is Part Of: Journal of biomedical materials research. Volume 102:Issue 4(2014:May)
• Page Start: 1037
• Page End: 1046
• Publication Date: 2013-06-04
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.a.34785
• Languages: English
• ISSNs: 1549-3296

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Calcium–phosphate ceramics, which have a composition similar to bone mineral, represent a potentially interesting synthetic bone graft substitute. In the present study, three porous hydroxyapatite (HA)/β‐tricalcium phosphate (β‐TCP)/collagen ceramic scaffolds were developed, characterized, and tested for their bone repairing capacity and osteoinductive potential in a New Zealand Rabbit model. The ratio of the ceramic components HA/‐TCP/collagen varied from 40/30/30 to 50/20/30 and 60/20/20 (in wt %), respectively. None of the ceramic scaffolds succeeded in completely bridging the 6 mm calvarian defect with new bone after 60 days implantation. 60/20/20 ceramic scaffolds showed significantly more bone formation in the pores and in the periphery of the graft than the other two materials. Histomorphometric analysis revealed that the 40/30/30 scaffold produced best bone‐to‐implant contact (67.23 ± 0.34% with higher quality, closer contact) in comparison with 50/20/30 (54.87 ± 0.32%), and 60/20/20 (48.53 ± 0.31%). Both physicochemical and structural properties of the ceramic composites affected their <italic>in vivo</italic> behavior, either dependently or independently, emphasizing the importance of assessing bone repair parameters individually. The scaffolds may offer clinical applications in reconstructive surgery for treating bone pathologies. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1037–1046, 2014.</p> </abstract>