Guardian of the Furnace: Mitochondria, TRAP1, ROS and stem cell maintenance. Issue 1 (30th December 2013)

• Record Type: Journal Article
• Authors: Kadye, Rose; Kramer, Adam H.; Joos‐Vandewalle, Julia; Parsons, Michelle; Njengele, Zikhona; Hoppe, Heinrich; Prinsloo, Earl
• Is Part Of: IUBMB life. Volume 66:Issue 1(2014:Jan.)
• Page Start: 42
• Page End: 45
• Publication Date: 2013-12-30
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; 572.8
• DOI: 10.1002/iub.1234
• Languages: English
• ISSNs: 1521-6543

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Mitochondria are key to eukaryotic cell survival and their activity is linked to generation of reactive oxygen species (ROS) which in turn acts as both an intracellular signal and an effective executioner of cells with regards to cellular senescence. The mitochondrial molecular chaperone tumor necrosis factor receptor associated protein 1 (TRAP1) is often termed the cytoprotective chaperone for its role in cancer cell survival and protection from apoptosis. Here, we hypothesize that TRAP1 serves to modulate mitochondrial activity in stem cell maintenance, survival and differentiation. © 2013 IUBMB Life, 66(1):42–45, 2014</p> </abstract>