Helicobacter pylori antibody responses and evolution of precancerous gastric lesions in a Chinese population. Issue 9 (7th November 2013)

• Record Type: Journal Article
• Authors: Pan, Kai‐Feng; Formichella, Luca; Zhang, Lian; Zhang, Yang; Ma, Jun‐Ling; Li, Zhe‐Xuan; Liu, Cong; Wang, Yu‐Mei; Goettner, Gereon; Ulm, Kurt; Classen, Meinhard; You, Wei‐Cheng; Gerhard, Markus
• Is Part Of: International journal of cancer. Volume 134:Issue 9(2014:May 01)
• Page Start: 2118
• Page End: 2125
• Publication Date: 2013-11-07
• Subjects: Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.28560
• Languages: English
• ISSNs: 0020-7136

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Helicobacter pylori</italic>‐specific proteins are involved in gastric carcinogenesis. To investigate the seroprevalence of six <italic>H. pylori</italic>‐specific antibodies in patients with different gastric histology, and the impact of seropositivities on the evolution of precancerous gastric lesions, a follow‐up study was conducted in Linqu County, China. The seropositivities for CagA, VacA, GroEL, UreA, HcpC and gGT were assessed by recomLine analysis in 573 <italic>H. pylori</italic>‐positive subjects and correlated with evolution of precancerous gastric lesions. We found that the score of <italic>H. pylori</italic> recomLine test was significantly increased in subjects with chronic atrophic gastritis (CAG, <italic>p</italic> < 0.0001) or intestinal metaplasia (IM, <italic>p</italic> = 0.0125), and CagA was an independent predictor of advanced gastric lesions, adjusted odds ratios (ORs) were 2.54 (95% CI = 1.42–4.55) for IM and 2.38 (95% CI = 1.05–5.37) for dysplasia (DYS). Moreover, seropositivities for CagA and GroEL were identified as independent predictors for progression of gastric lesions in a longitudinal study, and ORs were 2.89 (95% CI = 1.27–6.59) and 2.20 (95% CI = 1.33–3.64), respectively. Furthermore, the risk of progression was more pronounced in subjects with more than three positive antigens (<italic>p</italic><sub>for trend</sub> = 0.0003). This population‐based study revealed that seropositivities for CagA and GroEL might be potential markers to identify patients infected with high‐risk <italic>H. pylori</italic> strains, which are related to the development of GC in a Chinese high‐risk population, and recomLine test might serve as a tool for risk stratification.</p> </abstract>