Genetic variant of AKT1 and AKTIP associated with late‐onset depression in a Brazilian population. (10th September 2013)

• Record Type: Journal Article
• Authors: Pereira, Patricia Araújo; Bicalho, Maria Aparecida Camargos; de, Edgar Nunes; Malloy‐Diniz, Leandro; Bozzi, Isadora Cristine Reis Sguizzato; Nicolato, Rodrigo; Valadão, Daniela Rosa; Miranda, Debora Marques; Romano‐Silva, Marco Aurélio
• Is Part Of: International journal of geriatric psychiatry. Volume 29:Number 4(2014:Apr.)
• Page Start: 399
• Page End: 405
• Publication Date: 2013-09-10
• Subjects: Geriatric psychiatry -- Periodicals; Geriatric Psychiatry -- Periodicals; 618.97689
• DOI: 10.1002/gps.4018
• Languages: English
• ISSNs: 0885-6230

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="gps4018-sec-0001" sec-type="section"> <title>Objectives</title> <p>Examine the association between polymorphisms in the <italic>AKT1</italic> and <italic>AKTIP</italic> genes and late‐onset depression (LOD). Major depressive disorder is one of the most prevalent neuropsychiatric diseases. LOD is a disorder that starts after 65 years old. AKT1 is a downstream enzyme that has been implicated in the pathogenesis of neurotransmitter‐related disorders, such as depression. The identification of a novel AKT1‐binding protein (AKTIP) was pointed as an important new target. AKTIP binds directly to AKT1, enhancing the phosphorylation of regulatory sites, and this modulation are affected by AKT1 activation. The association of AKT1 and AKTIP polymorphisms with depressive symptoms was not investigated in LOD.</p> </sec> <sec id="gps4018-sec-0112" sec-type="section"> <title>Design</title> <p>Genotype tagSNPs in the AKT1 and AKTIP in LOD patients and controls.</p> </sec> <sec id="gps4018-sec-0122" sec-type="section"> <title>Settings</title> <p>An academic medical center.</p> </sec> <sec id="gps4018-sec-0113" sec-type="section"> <title>Participants</title> <p>Sample composed by 190 outpatients with LOD and 77 healthy individuals.</p> </sec> <sec id="gps4018-sec-0103" sec-type="section"> <title>Measures</title> <p>The participants were evaluated using Diagnostic and Statistical Manual IV criteria, MINI‐PLUS and the Geriatric Depression Scale.</p> </sec> <sec id="gps4018-sec-0104" sec-type="section"> <title>Results</title> <p>Our findings suggested an association between the tagSNP <italic>rs3730358</italic> homozygous A/A (<italic>p</italic> = 0.006) and LOD. A strong association of allele A and increased association for LOD was demonstrated with tagSNP <italic>rs3730358</italic> (<italic>p</italic>‐value = 0.003).</p> </sec> <sec id="gps4018-sec-0106" sec-type="section"> <title>Limitations</title> <p>Limitation include composition of our control group, where the exclusion criteria generated a kind of super‐healthy older group what might have produced a hidden stratification when compared with the LOD.</p> </sec> <sec id="gps4018-sec-0102" sec-type="section"> <title>Conclusion</title> <p>This study is the first one to establish the association of the <italic>AKT1</italic>/<italic>AKTIP</italic> genes and LOD, and further studies are necessary to clarify the functional role of these proteins. Copyright © 2013 John Wiley & Sons, Ltd.</p> </sec> </abstract>