Β‐arrestin‐1 mediates the TCR‐triggered re‐routing of distal receptors to the immunological synapse by a PKC‐mediated mechanism. (6th February 2014)

• Record Type: Journal Article
• Authors: Fernández‐Arenas, Elena; Calleja, Enrique; Martínez‐Martín, Nadia; Gharbi, Severine I; Navajas, Rosana; García‐Medel, Noel; Penela, Petronila; Alcamí, Antonio; Mayor, Federico; Albar, Juan P; Alarcón, Balbino
• Is Part Of: EMBO journal. Volume 33:Number 6(2014)
• Page Start: 559
• Page End: 577
• Publication Date: 2014-02-06
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.1002/embj.201386022
• Languages: English
• ISSNs: 0261-4189

Abstract

<abstract abstract-type="synopsis" xml:lang="en" id="embj201386022-abs-0002"> <title>Synopsis</title> <p> <boxed-text content-type="graphic" id="embj201386022-blkfxd-0001" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4st0ckbn" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> <p>Activated T‐cell receptors (TCRs) employ β‐arrestin‐mediated internalization to downregulate migratory chemokine receptors, but surprisingly also to recruit unliganded peripheral TCRs to the immunological synapse.</p> <p> <list id="embj201386022-list-0001" list-type="bullet"> <list-item> <p>β‐arrestin‐1 binds non‐phosphorylated tyrosine containing motifs, ITAMs, of the TCR.</p> </list-item> <list-item> <p>TCR triggering stimulates the phosphorylation by PKC of Ser163 in the phosphate sensor sequence of β‐arrestin‐1.</p> </list-item> <list-item> <p>Ser163 phosphorylation is required for β‐arrestin‐1 recruitment to the TCR.</p> </list-item> <list-item> <p>β‐arrestin‐1 is required for the TCR triggered downregulation of bystander TCRs and CXCR4.</p> </list-item> <list-item> <p>β‐arrestin‐1‐mediated downregulation of distal TCRs allows the immunological synapse to be fed with new TCRs and to sustain the TCR signal.</p> </list-item> </list> </p> </abstract>