Hormone‐induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure. (15th January 2014)

• Record Type: Journal Article
• Authors: Wikstrom, Jakob D; Mahdaviani, Kiana; Liesa, Marc; Sereda, Samuel B; Si, Yaguang; Las, Guy; Twig, Gilad; Petrovic, Natasa; Zingaretti, Cristina; Graham, Adam; Cinti, Saverio; Corkey, Barbara E; Cannon, Barbara; Nedergaard, Jan; Shirihai, Orian S
• Is Part Of: EMBO journal. Volume 33:Number 5(2014)
• Page Start: 418
• Page End: 436
• Publication Date: 2014-01-15
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.1002/embj.201385014
• Languages: English
• ISSNs: 0261-4189

Abstract

<abstract abstract-type="synopsis" xml:lang="en" id="embj201385014-abs-0002"> <title>Synopsis</title> <p> <boxed-text content-type="graphic" id="embj201385014-blkfxd-0001" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4sxhcz5j" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> <p>In this study, norepinephrine‐mediated mitochondrial dynamics are shown to contribute to uncoupled respiration during thermogenesis in brown adipocytes.</p> <p> <list id="embj201385014-list-0001" list-type="bullet"> <list-item> <p>Norepinephrine induced complete and rapid mitochondrial fragmentation in brown adipocytes through PKA‐dependent Drp1 phosphorylation and Opa1 cleavage.</p> </list-item> <list-item> <p>Norepinephrine‐induced mitochondrial uncoupling was reduced by inhibition of mitochondrial fission and enhanced by Mfn2 knock down.</p> </list-item> <list-item> <p>Knockdown of Mfn2 enhanced the capacity of exogenous free fatty acids to increase energy expenditure.</p> </list-item> <list-item> <p>We conclude that in addition to its ability to stimulate lipolysis, norepinephrine induces energy expenditure in brown adipocytes by promoting mitochondrial fragmentation.</p> </list-item> </list> </p> </abstract>