Wnt‐induced transcriptional activation is exclusively mediated by TCF/LEF. (10th January 2014)

• Record Type: Journal Article
• Authors: Schuijers, Jurian; Mokry, Michal; Hatzis, Pantelis; Cuppen, Edwin; Clevers, Hans
• Is Part Of: EMBO journal. Volume 33:Number 2(2014)
• Page Start: 146
• Page End: 156
• Publication Date: 2014-01-10
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.1002/embj.201385358
• Languages: English
• ISSNs: 0261-4189

Abstract

<abstract abstract-type="synopsis" xml:lang="en" id="embj201385358-abs-0002"> <title>Synopsis</title> <p> <boxed-text content-type="graphic" id="embj201385358-blkfxd-0001" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4snhvwsw" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> <p>Integrated genome‐wide ChIP‐seq data in multiple cell types reveals that Tcf4 globally determines Wnt/beta‐catenin transcriptional programs.</p> <p> <list id="embj201385358-list-0001" list-type="bullet"> <list-item> <p>β‐catenin‐bound elements can be divided in two classes according to TCF4 co‐occupancy.</p> </list-item> <list-item> <p>However, all β‐catenin was displaced by a dominant negative form of TCF4.</p> </list-item> <list-item> <p>These data show that β‐catenin recruitment is overwhelmingly mediated by TCF/LEF.</p> </list-item> </list> </p> </abstract>