Tumor‐propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis. (21st February 2014)

• Record Type: Journal Article
• Authors: Lau, Allison N; Curtis, Stephen J; Fillmore, Christine M; Rowbotham, Samuel P; Mohseni, Morvarid; Wagner, Darcy E; Beede, Alexander M; Montoro, Daniel T; Sinkevicius, Kerstin W; Walton, Zandra E; Barrios, Juliana; Weiss, Daniel J; Camargo, Fernando D; Wong, Kwok‐Kin; Kim, Carla F
• Is Part Of: EMBO journal. Volume 33:Number 5(2014)
• Page Start: 468
• Page End: 481
• Publication Date: 2014-02-21
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.1002/embj.201386082
• Languages: English
• ISSNs: 0261-4189

Abstract

<abstract abstract-type="synopsis" xml:lang="en" id="embj201386082-abs-0002"> <title>Synopsis</title> <p> <boxed-text content-type="graphic" id="embj201386082-blkfxd-0001" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4sxhd1dx" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> The molecular characterization of tumor‐propagating cells in mouse models of lung cancer reveals CD24⁺/Sca1⁺ and increased Yap/Taz activity as predictive for tumor metastasis. <list id="embj201386082-list-0001" list-type="bullet"><list-item><p>Murine lung TPCs with the markers Sca1 and CD24 are enriched for metastatic potential in orthotopic transplantation assays.</p></list-item><list-item><p>In lung cancer patient data sets, metastatic spread and patient survival could be stratified with a murine lung TPC gene signature.</p></list-item><list-item><p>Knockdown of the Hippo mediators Yap1 or Taz decreased migration and metastatic potential of lung cancer cells.</p></list-item><list-item><p>Yap activation was sufficient for driving tumor progression in the Kras mouse model of lung cancer.</p></list-item></list></p> </abstract>