The SCFSlimb E3 ligase complex regulates asymmetric division to inhibit neuroblast overgrowth. (10th January 2014)

• Record Type: Journal Article
• Authors: Li, Song; Wang, Cheng; Sandanaraj, Edwin; Aw, Sherry S Y; Koe, Chwee T; Wong, Jack J L; Yu, Fengwei; Ang, Beng T; Tang, Carol; Wang, Hongyan
• Is Part Of: EMBO reports. Volume 15:Number 2(2014:Feb.)
• Page Start: 165
• Page End: 174
• Publication Date: 2014-01-10
• Subjects: Molecular biology -- Periodicals; Molecular Biology -- Periodicals; Molecular biology; Periodicals; 572.8
• DOI: 10.1002/embr.201337966
• Languages: English
• ISSNs: 1469-221X

Abstract

<abstract abstract-type="synopsis" xml:lang="en" id="embr201337966-abs-0002"> <title>Synopsis</title> <p> <boxed-text content-type="graphic" id="embr201337966-blkfxd-0001" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4sngnw65" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> <p>This report provides evidence that loss of the SCF^Slimb E3 ubiquitin ligase complex as well as hyperactivation of Akt lead to neuroblast overgrowth and defects in asymmetric cell division. Slimb, the F‐box protein of the SCF complex, associates with Akt in a protein complex, and SCF^Slimb acts through SAK and Akt to inhibit neuroblast overgrowth.</p> <p> <list id="embr201337966-list-0001" list-type="bullet"> <list-item> <p>The SCF^S^limb E3 ubiquitin ligase inhibits neuroblast (NB) overgrowth and regulates asymmetric division of NBs.</p> </list-item> <list-item> <p>The NB overgrowth phenotype in the absence of SCF^S^limb is similar to what is seen in conditions of AKT hyperactivation.</p> </list-item> <list-item> <p>The F‐box protein Slimb associates with AKT and regulates NB overgrowth via SAK and AKT.</p> </list-item> </list> </p> </abstract>