FGF23 promotes renal calcium reabsorption through the TRPV5 channel. (17th January 2014) - Andrukhova, Olena
Synopsis αKlotho acts as a co‐receptor for the phosphaturic hormone FGF23 but can also activate TRPV5 channels via altered glycosylation patterns. Similar defects in αKlotho‐ and FGF23‐deficient mice along with FGF23‐controlled TRPV5 membrane localization suggest that the former pathway reflects αKlotho's in vivo function in renal calcium reabsorption. FGF23 activates SGK1 and WNK4 in renal distal tubules through its canonical, αKlotho‐ and FGF receptor‐dependent signaling pathway. FGF23 regulates membrane transport and activity of epithelial calcium channel TRPV5 via SGK1 and WNK4, augmenting distal renal tubular calcium reabsorption. FGF23 is not only a phosphaturic, but also a calcium‐conserving hormone.