Diamine oxidase activity levels in anorexia nervosa. Issue 2 (30th October 2013)

• Record Type: Journal Article
• Authors: Takimoto, Yoshiyuki; Yoshiuchi, Kazuhiro; Shimodaira, Satoshi; Akabayashi, Akira
• Is Part Of: International journal of eating disorders. Volume 47:Issue 2(2014:Mar.)
• Page Start: 203
• Page End: 205
• Publication Date: 2013-10-30
• Subjects: Appetite disorders -- Periodicals; Ingestion disorders -- Periodicals; Eating disorders -- Periodicals; 616.8526
• DOI: 10.1002/eat.22202
• Languages: English
• ISSNs: 0276-3478

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="eat22202-sec-0001" sec-type="section"> <title>Objective</title> <p>Anorexia nervosa (AN) patients often experience gastrointestinal complications caused by their malnutrition. We hypothesized that intestinal integrity is disturbed in AN. Therefore, the objective of the present study was to investigate serum diamine oxidase (DAO) activity, which is considered to be a clinical indicator of the integrity of the intestinal mucosa, in AN patients.</p> </sec> <sec id="eat22202-sec-0002" sec-type="section"> <title>Method</title> <p>Thirty‐six AN female patients including 21 AN restricting type (AN‐R) and 15 AN binge‐eating/purging type (AN‐BP) were compared with twenty healthy women on serum DAO activity using immunoassay.</p> </sec> <sec id="eat22202-sec-0003" sec-type="section"> <title>Results</title> <p>DAO levels in AN‐R patients were significantly lower than in AN‐BP patients and healthy controls.</p> </sec> <sec id="eat22202-sec-0004" sec-type="section"> <title>Discussion</title> <p>DAO levels were decreased in AN‐R patients. This finding suggests the presence of intestinal structural disturbance as one of the physical complications of malnutrition in AN‐R patients. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:203–205)</p> </sec> </abstract>