Encapsulated Ruthenium(II) Complexes in Biocompatible Poly(d, l‐lactide‐co‐glycolide) Nanoparticles for Application in Photodynamic Therapy. Issue 1 (7th January 2014)

• Record Type: Journal Article
• Authors: Bœuf, Gaëlle; Roullin, Gaëlle V.; Moreau, Juliette; Van Gulick, Laurence; Zambrano Pineda, Nebraska; Terryn, Christine; Ploton, Dominique; Andry, Marie Christine; Chuburu, Françoise; Dukic, Sylvain; Molinari, Michaël; Lemercier, Gilles
• Is Part Of: ChemPlusChem. Volume 79:Issue 1(2014:Jan.)
• Page Start: 171
• Page End: 180
• Publication Date: 2014-01-07
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cplu.201300242
• Languages: English
• ISSNs: 2192-6506

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The elaboration, characterisation and efficiency of potential two‐photon‐excited photodynamic therapy (PDT) treatment of new poly(<sc>d, l</sc>‐lactide‐<italic>co</italic>‐glycolide) nanoparticles loaded with ruthenium(II) complexs are presented. The materials are based on the encapsulation of Ru^II complexes through an all‐biocompatible process. The size of the nanoparticles is around 100 nm. The internal concentration is several orders of magnitude higher than the overall concentration, which leads to a more efficient and targeted effect. The therapeutic potential for PDT of these nanoparticles has been studied in vitro on C6 glioma cells.</p> </abstract>