Quantitation of a spin polarization‐induced nuclear Overhauser effect (SPINOE) between a hyperpolarized 13C‐labeled cell metabolite and water protons. (March 2014)

• Record Type: Journal Article
• Authors: Marco‐Rius, Irene; Bohndiek, Sarah E.; Kettunen, Mikko I.; Larkin, Timothy J.; Basharat, Meer; Seeley, Colm; Brindle, Kevin M.
• Is Part Of: Contrast media & molecular imaging. Volume 9:Number 2(2014:Mar./Apr.)
• Page Start: 182
• Page End: 186
• Publication Date: 2014-03
• Subjects: Diagnostic imaging -- Periodicals; Magnetic resonance imaging -- Periodicals; Contrast media (Diagnostic imaging) -- Periodicals; Contrast Media -- Periodicals; Diagnostic Imaging -- Periodicals; Substances de contraste -- Périodiques; Diagnostics moléculaires -- Périodiques; Imagerie médicale; Substance de contraste; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.0754
• DOI: 10.1002/cmmi.1556
• Languages: English
• ISSNs: 1555-4309

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The spin polarization‐induced nuclear Overhauser effect (SPINOE) describes the enhancement of spin polarization of solvent nuclei by the hyperpolarized spins of a solute. In this communication we demonstrate that SPINOEs can be observed between [1, 4‐¹³C₂]fumarate, hyperpolarized using the dissolution dynamic nuclear polarization technique, and solvent water protons. We derive a theoretical expression for the expected enhancement and demonstrate that this fits well with experimental measurements. Although the magnitude of the effect is relatively small (around 2% measured here), the SPINOE increases at lower field strengths, so that at clinically relevant magnetic fields (1.5–3 T) it may be possible to track the passage through the circulation of a bolus containing a hyperpolarized ¹³C‐labeled substrate through the increase in solvent water ¹H signal. © 2014 The Authors. <italic>Contrast Media &amp; Molecular Imaging</italic> published by John Wiley and Sons, Ltd.</p> </abstract>