A Template‐Based Approach to Inhibitors of Calpain 2, 20S Proteasome, and HIV‐1 Protease. Issue 12 (15th October 2013)

• Record Type: Journal Article
• Authors: Jones, Seth A.; Neilsen, Paul M.; Siew, Limei; Callen, David F.; Goldfarb, Nathan E.; Dunn, Ben M.; Abell, Andrew D.
• Is Part Of: ChemMedChem. Volume 8:Issue 12(2013:Dec.)
• Page Start: 1918
• Page End: 1921
• Publication Date: 2013-10-15
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201300387
• Languages: English
• ISSNs: 1860-7179

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Specificity counts:</bold> A template‐based approach to protease inhibitors is presented using a core macrocycle that presents a generic β‐strand template for binding to protease active sites. This is then specifically functionalized at P₂, and the C and N termini to give inhibitors of calpain 2, 20S proteasome, and HIV‐1 protease.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t7ncdg4" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>