Back Cover: Glucosylceramide Mimics: Highly Potent GCase Inhibitors and Selective Pharmacological Chaperones for Mutations Associated with Types 1 and 2 Gaucher Disease (ChemMedChem 11/2013). Issue 11 (28th October 2013)

• Record Type: Journal Article
• Authors: Schönemann, Wojciech; Gallienne, Estelle; Ikeda‐Obatake, Kyoko; Asano, Naoki; Nakagawa, Shinpei; Kato, Atsushi; Adachi, Isao; Górecki, Marcin; Frelek, Jadwiga; Martin, Olivier R.
• Is Part Of: ChemMedChem. Volume 8:Issue 11(2013:Nov.)
• Page Start: 1896
• Page End: 1896
• Publication Date: 2013-10-28
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201390049
• Languages: English
• ISSNs: 1860-7179

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The back cover picture shows</bold> the structure of glucocerebrosidase in complex with its substrate, glucosylceramide (GlcCer), and the structure of an iminoglycolipid acting as a mimic of GlcCer. This compound is a very potent inhibitor of glucocerebrosidase and exhibits significant chaperone effect on the N370S and L444P mutations, which are responsible for type 1 and type 2 Gaucher disease, respectively. For more details, see the Full Paper by Olivier R. Martin et al. on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">p. 1805 ff.</ext-link><boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t7mng9t" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>