An Efficient Combinatorial Synthesis of Allocolchicine Analogues via a Triple Cascade Reaction and their Evaluation as Inhibitors of Insulin Aggregation. Issue 11 (5th September 2013)

• Record Type: Journal Article
• Authors: Bhowmik, Subhendu; Khanna, Shruti; Srivastava, Kumkum; Hasanain, Mohammad; Sarkar, Jayanta; Verma, Sandeep; Batra, Sanjay
• Is Part Of: ChemMedChem. Volume 8:Issue 11(2013:Nov.)
• Page Start: 1767
• Page End: 1772
• Publication Date: 2013-09-05
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201300302
• Languages: English
• ISSNs: 1860-7179

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A controlled cascade:</bold> A divergent, diastereoselective and efficient one‐pot synthesis of allocolchicinoids via a cascade Suzuki–Michael addition–Carbocyclization sequence is described. The utility of the compounds as possible inhibitors of insulin aggregation is also presented.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t7mnm67" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>