Chromatographic Separation and Assignment of Absolute Configuration of Hydroxywarfarin Isomers. Issue 2 (13th December 2013)

• Record Type: Journal Article
• Authors: Regalado, Erik L.; Sherer, Edward C.; Green, Mitchell D.; Hendersonl, Derek W.; Thomas Williamson, R.; Joyce, Leo A.; Welch, Christopher J.
• Is Part Of: Chirality. Volume 26:Issue 2(2014:Feb.)
• Page Start: 95
• Page End: 101
• Publication Date: 2013-12-13
• Subjects: Chirality -- Periodicals; Pharmaceutical chemistry -- Periodicals; 541.22
• DOI: 10.1002/chir.22274
• Languages: English
• ISSNs: 0899-0042

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>The absolute configuration of several hydroxywarfarin isomers was assigned using a comparison of elution order on chiral stationary phases, optical rotation, and circular dichroism (CD) spectra, with confirmation of assignments made by comparison between experimental and calculated CD spectra and selective synthesis of hydroxywarfarin isomers from enantiopure warfarin using human liver microsomes. <italic>Chirality 26:95–101, 2014</italic>. © 2013 Wiley Periodicals, Inc.</p> </abstract>