A Nucleobase Analogue that Pairs Strongly with Adenine1. Issue 41 (23rd August 2013) - Minuth, Marco
Abstract Shaping up for an A: Adenine is the only canonical nucleobase that does not offer a third hydrogen‐bonding functionality at its Watson–Crick face, making it difficult to bind with high affinity. A 6‐ethynyl‐2‐pyridone binds more tightly and with greater sequence fidelity than thymine. VdW=van der Waals interactions.