Identification of Malate Dehydrogenase 2 as a Target Protein of the HIF‐1 Inhibitor LW6 using Chemical Probes1. Issue 39 (9th August 2013)

• Record Type: Journal Article
• Authors: Lee, Kyeong; Ban, Hyun Seung; Naik, Ravi; Hong, Ye Seul; Son, Seohyun; Kim, Bo‐Kyung; Xia, Yan; Song, Kyung Bin; Lee, Hong‐Sub; Won, Misun
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 39(2013)
• Page Start: 10286
• Page End: 10289
• Publication Date: 2013-08-09
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201304987
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Tracking the target</bold>: To identify a protein that binds directly to the HIF‐1α inhibitor LW6, a series of new chemical probes were synthesized with a clickable tag and/or a photoactivatable moiety. LW6 was found to be localized to the mitochondria (see picture) and MDH2 was identified as a target protein of LW6. These results indicate that the HIF‐1α inhibitory activity of LW6 is a consequence of MDH2 suppression.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg3h9k593s" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>