Acid‐Catalyzed Direct Conjugate Alkenylation of α, β‐Unsaturated Ketones1. Issue 40 (12th August 2013) - Okamoto, Kazuhiro
Abstract New tricks, old reaction: The title reaction proceeds under mild and transition‐metal‐free conditions (see scheme; Tf=trifluoromethanesulfonyl). Various combinations of substrates are applicable to the synthesis of γ, δ‐unsaturated ketones by employing silicon substituents at the β‐position of the enones. The silicon substituents play a key role in stabilization of the cationic intermediate by hyperconjugation.