A Powerful Hydrogen‐Bond‐Donating Organocatalyst for the Enantioselective Intramolecular Oxa‐Michael Reaction of α, β‐Unsaturated Amides and Esters1. Issue 42 (27th August 2013)

• Record Type: Journal Article
• Authors: Kobayashi, Yusuke; Taniguchi, Yamato; Hayama, Noboru; Inokuma, Tsubasa; Takemoto, Yoshiji
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 42(2013)
• Page Start: 11114
• Page End: 11118
• Publication Date: 2013-08-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201305492
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Tuning the organocatalyst</bold>: An unprecedented enantioselective intramolecular oxa‐Michael reaction of unactivated α, β‐unsaturated amides and esters catalyzed by a powerful hydrogen‐bond‐donating organocatalyst has been developed. Furthermore, the products obtained from this reaction have been used for the straightforward asymmetric synthesis of several natural products and biologically important compounds.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg3kg2jp1s" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>