Rhodium‐Catalyzed Boron Arylation of 1, 2‐Azaborines1. Issue 35 (5th July 2013)

• Record Type: Journal Article
• Authors: Rudebusch, Gabriel E.; Zakharov, Lev N.; Liu, Shih‐Yuan
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 35(2013)
• Page Start: 9316
• Page End: 9319
• Publication Date: 2013-07-05
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201304443
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A Sn‐phony in B!</bold> BN isosteres of biphenyl compounds are prepared through Rh‐catalyzed cross‐coupling between 2‐chloro‐1, 2‐azaborines and arylstannanes (see scheme). The synthetic method should enable investigations of structure–activity relationships (SARs) by expanding the chemical space of the pharmaceutically relevant biphenyl structure through BN/CC isosterism.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg36jzx7dr" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>