Chemoselective Peptide Ligation–Desulfurization at Aspartate1. Issue 37 (24th July 2013)

• Record Type: Journal Article
• Authors: Thompson, Robert E.; Chan, Bun; Radom, Leo; Jolliffe, Katrina A.; Payne, Richard J.
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 37(2013)
• Page Start: 9723
• Page End: 9727
• Publication Date: 2013-07-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201304793
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Asp‐ecially useful</bold>: A synthetic β‐mercapto aspartate residue facilitates the rapid ligation to a range of peptide thioesters. Following the ligation reaction (and without purification), chemoselective desulfurization of the β‐mercapto moiety in the presence of unprotected cysteine residues afforded native peptide products.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg36jzw983" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>