Asymmetric Electrophilic Fluorocyclization with Carbon Nucleophiles1. Issue 37 (22nd July 2013)

• Record Type: Journal Article
• Authors: Wolstenhulme, Jamie R.; Rosenqvist, Jessica; Lozano, Oscar; Ilupeju, John; Wurz, Nathalie; Engle, Keary M.; Pidgeon, George W.; Moore, Peter R.; Sandford, Graham; Gouverneur, Véronique
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 37(2013)
• Page Start: 9796
• Page End: 9800
• Publication Date: 2013-07-22
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201304845
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Twist of 'F'ate</bold>: Various helical‐shaped fluorinated tetracyclic molecules were prepared by fluorocarbocyclization of prochiral alkenes. The development of a new class of chiral Selectfluor (<bold>1</bold>) proved instrumental in developing an asymmetric variant of this transformation. These novel chiral N‐F reagents are readily accessible by fluorine transfer from shelf‐stable <italic>N</italic>‐fluoropyridinium salts.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg36jzwzn0" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>