Copper‐Catalyzed Regioselective Intramolecular Oxidative α‐Functionalization of Tertiary Amines: An Efficient Synthesis of Dihydro‐1, 3‐Oxazines1. Issue 37 (24th July 2013) - Deb, Mohit L.
Abstract Traffic control: The hydroxy functional group directs the α‐functionalization of tertiary amines, synthesizing 1, 3‐oxazines by CO bond formation. Reaction occurs with both benzylic and non‐benzylic amines. In the case of naphthoxazine synthesis, 100 % diastereoselectivity was observed. A tentative two‐pathway mechanism is proposed for the reaction.