Sandmeyer Trifluoromethylation of Arenediazonium Tetrafluoroborates1. Issue 31 (5th July 2013)

• Record Type: Journal Article
• Authors: Danoun, Grégory; Bayarmagnai, Bilguun; Grünberg, Matthias F.; Gooßen, Lukas J.
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 31(2013)
• Page Start: 7972
• Page End: 7975
• Publication Date: 2013-07-05
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201304276
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Copper capabilities</bold>: Diazonium salts are converted into the corresponding trifluoromethyl derivatives in the presence of a trifluoromethyl–copper complex generated in situ from CuSCN and the inexpensive, easy‐to‐use trifluoromethylating reagent Me₃Si‐CF₃ (see scheme). This Sandmeyer‐type reaction allows the straightforward synthesis of trifluoromethylated arenes and heteroarenes from the corresponding amines.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg276x43s3" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>