Mesoporous Silica Nanoparticle Pretargeting for PET Imaging Based on a Rapid Bioorthogonal Reaction in a Living Body1. Issue 40 (16th August 2013)

• Record Type: Journal Article
• Authors: Lee, Sang Bong; Kim, Hye Lan; Jeong, Hwan‐Jeong; Lim, Seok Tae; Sohn, Myung‐Hee; Kim, Dong Wook
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 40(2013)
• Page Start: 10549
• Page End: 10552
• Publication Date: 2013-08-16
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201304026
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Last‐minute labeling</bold>: Mesoporous silica nanoparticles (MSNs) were modified with a very short half‐life fluorine‐18‐labeled azide radiotracer by a cycloaddition reaction after the MSNs had reached the tumor site in mice. The tumor could then be visualized successfully with positron emission tomography.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg3h9m376w" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>