Back Cover: Mix to Validate: A Facile, Reversible PEGylation for Fast Screening of Potential Therapeutic Proteins In Vivo (Angew. Chem. Int. Ed. 27/2013). Issue 27 (6th June 2013)

• Record Type: Journal Article
• Authors: Kim, Tae Hyung; Swierczewska, Magdalena; Oh, Yumin; Kim, AeRyon; Jo, Dong Gyu; Park, Jae Hyung; Byun, Youngro; Sadegh‐Nasseri, Scheherazade; Pomper, Martin G.; Lee, Kang Choon; Lee, Seulki
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 27(2013)
• Page Start: 7044
• Page End: 7044
• Publication Date: 2013-06-06
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201304233
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Increasing the half‐life</bold> of therapeutic proteins in a specific, fast, and reliable way could greatly benefit the discovery of novel protein drugs. In their Communication on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 6880 ff.</ext-link>, K. C. Lee, S. Lee, and co‐workers conjugate Ni‐NTA to poly(ethylene glycol) and then label oligohistidine‐tagged therapeutic proteins to improve their stability in vivo without compromising bioactivity.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg22f1qwxr" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>