Palladium‐ and Ruthenium‐Catalyzed Cycloisomerization of Enynamides and Enynhydrazides: A Rapid Approach to Diverse Azacyclic Frameworks1. Issue 35 (15th July 2013)

• Record Type: Journal Article
• Authors: Walker, P. Ross; Campbell, Craig D.; Suleman, Abid; Carr, Greg; Anderson, Edward A.
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 35(2013)
• Page Start: 9139
• Page End: 9143
• Publication Date: 2013-07-15
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201304186
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>I want to ride my azacycle:</bold> The title reaction of enynamides affords a wide diversity of azacycles. The reactions are high‐yielding, highly stereoselective, and proceed rapidly under mild reaction conditions. Equivalent transformations using enynhydrazides offer new routes to pyrazole and indazole scaffolds. Boc=<italic>tert</italic>‐butoxycarbonyl, EWG=electron‐withdrawing group, Ns=4‐nitrobenzenesulfonyl, Ts=4‐toluenesulfonyl.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg36jzxjrx" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>