Chemical Synthesis of Biologically Active Monoglycosylated GM2‐Activator Protein Analogue Using N‐Sulfanylethylanilide Peptide1. Issue 30 (13th June 2013) - Sato, Kohei
Abstract Going to SEA(lide): Total chemical synthesis of a 162‐residue glycoprotein analogue of the monoglycosylated human GM2‐activator protein (GM2AP) was achieved. Key steps were the use of N‐sulfanylethylanilide (SEAlide) peptides in the kinetic chemical ligation synthesis of a large peptide fragment, and a convergent native chemical ligation for final fragment assembly.