Rh/Pd Catalysis with Chiral and Achiral Ligands: Domino Synthesis of Aza‐Dihydrodibenzoxepines1. Issue 37 (19th July 2013)

• Record Type: Journal Article
• Authors: Friedman, Adam A.; Panteleev, Jane; Tsoung, Jennifer; Huynh, Vaizanne; Lautens, Mark
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 37(2013)
• Page Start: 9755
• Page End: 9758
• Publication Date: 2013-07-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201303659
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A game of dominoes</bold>: A synthetic route to aza‐dihydrodibenzoxepines is described, through the combination of a Rh‐catalyzed arylation and a Pd‐catalyzed C‐O coupling in a single pot. For the first time, the ability to incorporate a chiral and an achiral ligand in a two‐component, two‐metal transformation is achieved, giving the products in moderate to good yields, with excellent enantioselectivities.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg36jzwn65" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>