Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid‐Anchored Peptide Vaccines1. Issue 41 (23rd August 2013)

• Record Type: Journal Article
• Authors: Koers, Eline J.; López‐Deber, Maria Pilar; Weingarth, Markus; Nand, Deepak; Hickman, David T.; Mlaki Ndao, Dorin; Reis, Pedro; Granet, Anne; Pfeifer, Andrea; Muhs, Andreas; Baldus, Marc
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 41(2013)
• Page Start: 10905
• Page End: 10908
• Publication Date: 2013-08-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201303374
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Sensitivity is the key</bold>: Dynamic nuclear polarization NMR spectroscopy provides structural information on liposomal vaccines targeting Alzheimer's disease. DMPC/DMPG/Cholesterol mainly stabilizes extended structures of the lipid‐anchored peptide, while in DMTAP/Cholesterol liposomes the peptide adopts a multitude of conformations including random‐coil and extended structures.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg3j1p0g0q" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>