Cover Picture: A Facile Strategy for Selective Incorporation of Phosphoserine into Histones (Angew. Chem. Int. Ed. 22/2013). Issue 22 (2nd May 2013)

• Record Type: Journal Article
• Authors: Lee, Sangsik; Oh, Seunghee; Yang, Aerin; Kim, Jihyo; Söll, Dieter; Lee, Daeyoup; Park, Hee‐Sung
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 22(2013)
• Page Start: 5651
• Page End: 5651
• Publication Date: 2013-05-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201303269
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic> <bold>Selective phosphoserine incorporation</bold> </italic> is described by H.‐S. Park et al. in their Communication on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 5771 ff.</ext-link> A general strategy for producing recombinant histones with site‐specific serine phosphorylation has been developed by engineering phosphoseryl‐tRNA synthethase (SepRS) and elongation factor Tu (EF‐Tu). This method should facilitate the study of histone phosphorylation and cross‐regulatory mechanisms.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg20p48xb3" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>