Anthracimycin, a Potent Anthrax Antibiotic from a Marine‐Derived Actinomycete1. Issue 30 (17th June 2013)

• Record Type: Journal Article
• Authors: Jang, Kyoung Hwa; Nam, Sang‐Jip; Locke, Jeffrey B.; Kauffman, Christopher A.; Beatty, Deanna S.; Paul, Lauren A.; Fenical, William
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 30(2013)
• Page Start: 7822
• Page End: 7824
• Publication Date: 2013-06-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201302749
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Licensed to kill</bold>: A new antibiotic, anthracimycin (see scheme), produced by a marine‐derived actinomycete in saline culture, shows significant activity toward <italic>Bacillus anthracis</italic>, the bacterial pathogen responsible for anthrax infections. Chlorination of anthracimycin gives a dichloro derivative that retains activity against Gram‐positive bacteria, such as anthrax, but also shows activity against selected Gram‐negative bacteria.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg270w436s" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>