A Controlled‐Release Nanocarrier with Extracellular pH Value Driven Tumor Targeting and Translocation for Drug Delivery1. Issue 29 (11th June 2013)

• Record Type: Journal Article
• Authors: Zhao, Zilong; Meng, Hongmin; Wang, Nannan; Donovan, Michael J.; Fu, Ting; You, Mingxu; Chen, Zhuo; Zhang, Xiaobing; Tan, Weihong
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 29(2013)
• Page Start: 7487
• Page End: 7491
• Publication Date: 2013-06-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201302557
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>This pHLIP is no flop</bold>: Functionalizing mesoporous silica nanoparticles (MSNs) with pHLIPss peptide provides a controlled‐release nanoparticle drug delivery system targeting the acidic tumor microenvironment. At low pH values, pHLIPss inserts into the cell membrane and translocates carriers into cells, where the cargo is released by the cleavage of the pHLIPss disulfide bonds (see scheme).<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg270vv53v" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>