Biomimetic Dehydrogenative Diels–Alder Cycloadditions: Total Syntheses of Brosimones A and B1. Issue 32 (1st July 2013)

• Record Type: Journal Article
• Authors: Qi, Chao; Cong, Huan; Cahill, Katharine J.; Müller, Peter; Johnson, Richard P.; Porco, John A.
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 32(2013)
• Page Start: 8345
• Page End: 8348
• Publication Date: 2013-07-01
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201302847
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Passing (H₂) gas</bold>: Concise syntheses of the natural products brosimones A and B have been achieved using sequential dehydrogenative Diels–Alder (DHDA) cycloadditions. The syntheses employ either Pt/C‐cyclopentene or DDQ to effect dehydrogenation of prenylchalcone substrates in combination with silver nanoparticles to promote subsequent Diels–Alder cycloadditions.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg36jxc7bg" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>