Directed Manipulation of a Flavoprotein Photocycle 1. Issue 32 (1st July 2013)

• Record Type: Journal Article
• Authors: Staudt, Heike; Hoesl, Michael Georg; Dreuw, Andreas; Serdjukow, Sascha; Oesterhelt, Dieter; Budisa, Nediljko; Wachtveitl, Josef; Grininger, Martin
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 32(2013)
• Page Start: 8463
• Page End: 8466
• Publication Date: 2013-07-01
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201302334
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Tamed electrons</bold>: To manipulate a protein photocycle in a directed manner, the flavoprotein dodecin was endoscopically modified at its key amino acid tryptophan with substituents carefully selected by their structural and electronic influence. The approach is ideal in the precision of rational protein engineering, and allows correlating tryptophan ionization potentials and electron transfer rates in a Marcus model.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg36jxc68v" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>