Optical Control of TRPV1 Channels1. Issue 37 (19th July 2013)

• Record Type: Journal Article
• Authors: Stein, Marco; Breit, Andreas; Fehrentz, Timm; Gudermann, Thomas; Trauner, Dirk
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 37(2013)
• Page Start: 9845
• Page End: 9848
• Publication Date: 2013-07-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201302530
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Controlling pain with light</bold>: TRPV1 channels mediate the response to noxious heat and can be activated by capsaicin, the major ingredient of chili pepper. Novel azobenzene photoswitches can be used for the optical control of TRPV1. One of these compounds antagonizes capsaicin in a light‐dependent fashion, demonstrating that a photoswitchable antagonist and an agonist can be applied in concert to modulate ion channel activity.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg36jzx65c" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>