Visualization and Isolation of Langerhans Islets by a Fluorescent Probe PiY1. Issue 33 (28th May 2013)

• Record Type: Journal Article
• Authors: Kang, Nam‐Young; Lee, Sung‐Chan; Park, Sung‐Jin; Ha, Hyung‐Ho; Yun, Seong‐Wook; Kostromina, Elena; Gustavsson, Natalia; Ali, Yusuf; Chandran, Yogeswari; Chun, Hang‐Suk; Bae, MyungAe; Ahn, Jin Hee; Han, Weiping; Radda, George K.; Chang, Young‐Tae
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 33(2013)
• Page Start: 8557
• Page End: 8560
• Publication Date: 2013-05-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201302149
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Lighting up the pancreas</bold>: A pancreatic beta cell selective probe <bold>PiY</bold> (red, see picture) was developed which stains Langerhans islets in live animals without toxicity or side effects. Through tail‐vein injection, <bold>PiY</bold> allowed for a comparison of the islets between healthy and diabetic mice. <bold>PiY</bold> also facilitated the isolation of healthy Langerhans islets by using a fluorescence‐guided surgical procedure.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg36jx43n0" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>