Design and Synthesis of Cyclic ADP‐4‐Thioribose as a Stable Equivalent of Cyclic ADP‐Ribose, a Calcium Ion‐Mobilizing Second Messenger1. Issue 26 (13th May 2013)

• Record Type: Journal Article
• Authors: Tsuzuki, Takayoshi; Sakaguchi, Natsumi; Kudoh, Takashi; Takano, Satoshi; Uehara, Masato; Murayama, Takashi; Sakurai, Takashi; Hashii, Minako; Higashida, Haruhiro; Weber, Karin; Guse, Andreas H.; Kameda, Tomoshi; Hirokawa, Takatsugu; Kumaki, Yasuhiro; Potter, Barry V. L.; Fukuda, Hayato; Arisawa, Mitsuhiro; Shuto, Satoshi
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 26(2013)
• Page Start: 6633
• Page End: 6637
• Publication Date: 2013-05-13
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201302098
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Oh, what a difference an S makes</bold>: A thioribose analogue (cADPtR, see scheme) of cyclic ADP‐ribose (cADPR) was synthesized that is stable and has structural and electrostatic features similar to those of cADPR. cADPtR is the first stable equivalent of cADPR that is as active as cADPR in various cellular systems, making it useful for investigating Ca²⁺ ion‐release signaling pathways.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg22f259jm" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>