The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand1. Issue 30 (20th June 2013) - Lockett, Matthew R.
Abstract It's the water that matters. Pairs of benzo‐ and perfluorobenzoarylsulfonamide ligands bind to human carbonic anhydrase with a conserved binding geometry, an enthalpy‐driven binding, and indistinguishable binding affinities (see picture). These data support the pervasive theory that the lock‐and‐key model disregards an important component of binding: the water, which fills the binding pocket of the protein and surrounds the ligand.